Ecological analysis of Pavlovian fear conditioning in rats | Panda Anku

  • Watson, J. B. & Morgan, J. J. B. Emotional reactions and psychological experimentation. Am. J. Psychol. 28, 163–174 (1917).

    Article 

    Google Scholar 

  • Watson, J. B. & Rayner, R. Conditioned emotional reactions. J. Exp. Psychol. 3, 1–14 (1920).

    Article 

    Google Scholar 

  • LeDoux, J. Fear and the brain: where have we been, and where are we going. Biol. Psychiatry 44, 1229–1238 (1998).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Fendt, M. & Fanselow, M. S. The neuroanatomical and neurochemical basis of conditioned fear. Neurosci. Biobehav. Rev. 23, 743–760 (1999).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Maren, S. & Quirk, G. J. Neuronal signalling of fear memory. Nat. Rev. Neurosci. 5, 844–852 (2004).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Bouton, M. E., Mineka, S. & Barlow, D. H. A modern learning theory perspective on the etiology of panic disorder. Psychol. Rev. 108, 4–32 (2001).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Kim, J. J. & Jung, M. W. Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. Neurosci. Biobehav. Rev. 30, 188–202 (2006).

    PubMed 
    Article 

    Google Scholar 

  • Watson, J. B. Psychology as the behaviorist views it. Psychological Rev. 20, 158–177 (1913).

    Article 

    Google Scholar 

  • Pavlov, I. P. Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex (Oxford University Press, 1927).

  • Guthrie, E. R. Conditioning as a principle of learning. Psychological Rev. 37, 412–428 (1930).

    Article 

    Google Scholar 

  • Kamin, L. J. in Miami Symposium on the Prediction of Behavior (ed. Jones, M. R.) 9–33 (University of Miami Press, 1968).

  • Rescorla, R. A. Probability of shock in the presence and absence of CS in fear conditioning. J. Comp. Physiol. Psychol. 66, 1–5 (1968).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Wagner, A. R., Logan, F. A., Haberlandt, K. & Price, T. Stimulus selection in animal discrimination learning. J. Exp. Psychol. 76, 171–180 (1968).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Rescorla, R. A. & Wagner, A. R. A Theory of Pavlovian Conditioning: Variations in the Effectiveness of Reinforcement and Nonreinforcement 64–99 (Appleton-Century-Crofts, 1972).

  • Josselyn, S. A. & Tonegawa, S. Memory engrams: recalling the past and imagining the future. Science 367, https://doi.org/10.1126/science.aaw4325 (2020).

  • Tovote, P., Fadok, J. P. & Luthi, A. Neuronal circuits for fear and anxiety. Nat. Rev. Neurosci. 16, 317–331 (2015).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Haubensak, W. et al. Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature 468, 270–276 (2010).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Foa, E. B. & Rothbaum, B. O. Treating the Trauma of Rape: Cognitive Behavioral Therapy for PTSD (Guilford Press, 1998).

  • Butler, A. C., Chapman, J. E., Forman, E. M. & Beck, A. T. The empirical status of cognitive-behavioral therapy: a review of meta-analyses. Clin. Psychol. Rev. 26, 17–31 (2006).

    PubMed 
    Article 

    Google Scholar 

  • Delgado, M. R., Olsson, A. & Phelps, E. A. Extending animal models of fear conditioning to humans. Biol. Psychol. 73, 39–48 (2006).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Mahan, A. L. & Ressler, K. J. Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci. 35, 24–35 (2012).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Craske, M. G. et al. What is an anxiety disorder? Focus 9, 20 (2011).

    Google Scholar 

  • LeDoux, J. E. The Emotional Brain: the Mysterious Underpinnings of Emotional Life (Simon & Schuster, 1996).

  • Fanselow, M. S. From contextual fear to a dynamic view of memory systems. Trends Cogn. Sci. 14, 7–15 (2010).

    PubMed 
    Article 

    Google Scholar 

  • Lima, S. L. & Dill, L. M. Behavioral decisions made under the risk of predation—a review and prospectus. Can. J. Zool. 68, 619–640 (1990).

    Article 

    Google Scholar 

  • Bednekoff, P. A. Foraging in the Face of Danger 305–329 (University of Chicago Press, 2007).

  • Stephens, D. W. Decision ecology: foraging and the ecology of animal decision making. Cogn. Affect Behav. Neurosci. 8, 475–484 (2008).

    PubMed 
    Article 

    Google Scholar 

  • Beckers, T., Krypotos, A. M., Boddez, Y., Effting, M. & Kindt, M. What’s wrong with fear conditioning? Biol. Psychol. 92, 90–96 (2013).

    PubMed 
    Article 

    Google Scholar 

  • Mobbs, D. & Kim, J. J. Neuroethological studies of fear, anxiety, and risky decision-making in rodents and humans. Curr. Opin. Behav. Sci. 5, 8–15 (2015).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Pellman, B. A. & Kim, J. J. What can ethobehavioral studies tell us about the Brain’s fear system. Trends Neurosci. 39, 420–431 (2016).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Thorndike, E. Biological Lectures from the Marine Laboratory at Woods’ Holl, USA, for 1899. Nature 62, 411 (1900).

  • Bolles, R. C. Species-specific defense reactions and avoidance learning. Psychol. Rev. 77, 32–48 (1970).

  • Choi, J. S. & Kim, J. J. Amygdala regulates risk of predation in rats foraging in a dynamic fear environment. Proc. Natl Acad. Sci. USA 107, 21773–21777 (2010).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Zambetti, P. R., Schuessler, B. P. & Kim, J. J. Sex differences in foraging rats to naturalistic aerial predator stimuli. iScience 16, 442–452 (2019).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Yilmaz, M. & Meister, M. Rapid innate defensive responses of mice to looming visual stimuli. Curr. Biol. 23, 2011–2015 (2013).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Papes, F., Logan, D. W. & Stowers, L. The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs. Cell 141, 692–703 (2010).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Tolman, E. C. Cognitive maps in rats and men. Psychol. Rev. 55, 189–208 (1948).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Wilensky, A. E., Schafe, G. E. & LeDoux, J. E. The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning. J. Neurosci. 20, 7059–7066 (2000).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Lee, T. & Kim, J. J. Differential effects of cerebellar, amygdalar, and hippocampal lesions on classical eyeblink conditioning in rats. J. Neurosci. 24, 3242–3250 (2004).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Stiedl, O. & Spiess, J. Effect of tone-dependent fear conditioning on heart rate and behavior of C57BL/6N mice. Behav. Neurosci. 111, 703–711 (1997).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Guimaraes, F. S., Hellewell, J., Hensman, R., Wang, M. & Deakin, J. F. Characterization of a psychophysiological model of classical fear conditioning in healthy volunteers: influence of gender, instruction, personality and placebo. Psychopharmacology 104, 231–236 (1991).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Mackintosh, N. J. The Psychology of Animal Learning (Academic Press, 1974).

  • Bouton, M. E. Learning and Behavior (Sinauer Associates 2007).

  • Sheafor, P. J. “Pseudoconditioned” jaw movements of the rabbit reflect associations conditioned to contextual background cues. J. Exp. Psychol. Anim. Behav. Process 1, 245–260 (1975).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Rescorla, R. A. Behavioral studies of Pavlovian conditioning. Annu. Rev. Neurosci. 11, 329–352 (1988).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Thompson, R. F. & Krupa, D. J. Organization of memory traces in the mammalian brain. Annu. Rev. Neurosci. 17, 519–549 (1994).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Fanselow, M. S. & Wassum, K. M. The origins and organization of vertebrate pavlovian conditioning. Cold Spring Harb. Perspect. Biol. 8, a021717 (2015).

    PubMed 
    Article 

    Google Scholar 

  • Lee, H. J., Berger, S. Y., Stiedl, O., Spiess, J. & Kim, J. J. Post-training injections of catecholaminergic drugs do not modulate fear conditioning in rats and mice. Neurosci. Lett. 303, 123–126 (2001).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Palgi, Y., Gelkopf, M. & Berger, R. The inoculating role of previous exposure to potentially traumatic life events on coping with prolonged exposure to rocket attacks: a lifespan perspective. Psychiatry Res. 227, 296–301 (2015).

    PubMed 
    Article 

    Google Scholar 

  • Somer, E. et al. Israeli civilians under heavy bombardment: prediction of the severity of post-traumatic symptoms. Prehosp. Disaster Med. 24, 389–394 (2009).

    PubMed 
    Article 

    Google Scholar 

  • Alexander, B. K., Beyerstein, B. L., Hadaway, P. F. & Coambs, R. B. Effect of early and later colony housing on oral ingestion of morphine in rats. Pharm. Biochem. Behav. 15, 571–576 (1981).

    CAS 
    Article 

    Google Scholar 

  • Gage, S. H. & Sumnall, H. R. Rat Park: how a rat paradise changed the narrative of addiction. Addiction 114, 917–922 (2019).

    PubMed 
    Article 

    Google Scholar 

  • Fanselow, M. S. & Lester, L. S. A Functional Behavioristic Approach to Aversively Motivated Behavior: Predatory Imminence as a Determinant of the Topography of Defensive Behavior 185–212 (Lawrence Erlbaum Associates Inc, 1988).

  • Cain, C. & LeDoux, J. Brain mechanisms of Pavlovian and instrumental aversive conditioning. Handb. Behav. Neurosci. 17, 103–124 (2008).

    Article 

    Google Scholar 

  • Choi, J. S., Cain, C. K. & LeDoux, J. E. The role of amygdala nuclei in the expression of auditory signaled two-way active avoidance in rats. Learn Mem. 17, 139–147 (2014).

    Article 

    Google Scholar 

  • Steimer, T. The biology of fear- and anxiety-related behaviors. Dialogues Clin. Neurosci. 4, 231–249 (2002).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Fanselow, M. S. The role of learning in threat imminence and defensive behaviors. Curr. Opin. Behav. Sci. 24, 44–49 (2018).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Fanselow, M. S. Associative vs topographical accounts of the immediate shock freezing deficit in rats—implications for the response selection-rules governing species-specific defensive reactions. Learn. Motiv. 17, 16–39 (1986).

    Article 

    Google Scholar 

  • Landeira-Fernandez, J., DeCola, J. P., Kim, J. J. & Fanselow, M. S. Immediate shock deficit in fear conditioning: effects of shock manipulations. Behav. Neurosci. 120, 873–879 (2006).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Hull, C. L. A functional interpretation of the conditioned reflex. Psychol. Rev. 36, 498–511 (1929).

    Article 

    Google Scholar 

  • Lazarus, A. A. Behavior Therapy and Beyond (McGraw-Hill Companies, 1971).

  • Öhman, A. & Mineka, S. Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. Psychol. Rev. 108, 483–522 (2001).

    PubMed 
    Article 

    Google Scholar 

  • Lee, H. & Kim, J. J. Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. J. Neurosci. 18, 8444–8454 (1998).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Mathis, A. et al. DeepLabCut: markerless pose estimation of user-defined body parts with deep learning. Nat. Neurosci. 21, 1281–1289 (2018).

    CAS 
    PubMed 
    Article 

    Google Scholar 

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